Research Library

Curated Studies & Clinical Data

A growing library of peer-reviewed studies, clinical trial data, and systematic reviews organized by compound. Every citation is linked to its primary source.

1093Curated Studies
28Compounds Covered
18Clinical Trials
550Journals Referenced
PRECLINICAL / IN VIVO

Sirtuin 1 deficiency mediates chronic kidney disease-induced inflammaging cardiovascular calcification

Xu L, Zheng Y, Liu M, et al.

Molecular biomedicine, 2026;7(1)

Semaglutide
PRECLINICAL / IN VIVO

Role of GLP-1 receptor agonists in the prevention and treatment of obesity-related cancer

Muscogiuri G, Del Vecchio G, Colangeli L, et al.

Internal and emergency medicine, 2026

GLP-1
PRECLINICAL / IN VIVO

Preventative semaglutide and tirzepatide treatment does not alter disease progression in the 5xFAD mouse model of Alzheimer’s disease

Vear A, Olsen SA, Lange ECH, et al.

Cell reports. Medicine, 2026;:102906

GLP-1 Semaglutide tirzepatide
PRECLINICAL / IN VIVO

A Sequential Dual GLP-1R/GIPR Agonist-To-Antagonist Molecule Achieves Superior Weight Loss in Obese Mice

Zhang Y, Zhu B, Peng B, et al.

Diabetes, obesity & metabolism, 2026

GLP-1 Semaglutide tirzepatide
PRECLINICAL / IN VIVO

Overcoming Gastric Barriers for Oral Peptide Delivery: QbD-Based Development of Sodium Caprate-Enabled Tirzepatide Tablets

Im S, Lee JY, Kim JE

Pharmaceutics, 2026;18(7)

GLP-1 Semaglutide tirzepatide
PRECLINICAL / IN VIVO

Quantitative MRI Pharmacokinetic Modeling and MALDI Mass Spectrometry Imaging Biodistribution of a pH Mapping MRI Contrast Agent

Mohanta Z, Tressler CM, Gori S, et al.

Theranostics, 2026;16(14):7937-7957

semax
PRECLINICAL / IN VIVO

Lead-guided prodrug development of small molecules as GLP-1R agonists

Lentschat H, Aboelfotouh HG, Nabil P, et al.

Bioorganic chemistry, 2026;180:110210

GLP-1 tirzepatide
PRECLINICAL / IN VIVO

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction

Guo J, Ma S, Ma J, et al.

Nature communications, 2026;17(1)

Semaglutide
PRECLINICAL / IN VIVO

Females Are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice

Rout S, Karasawa T, Watanabe S, et al.

Diabetes, 2026

Semaglutide
PRECLINICAL / IN VIVO

Effects of Retatrutide on Learning and Memory in Streptozotocin-Induced Male Diabetic Rats

Keskin U, Altin E, Kara MK, et al.

Behavioural brain research, 2026;:116343

GLP-1 retatrutide
PRECLINICAL / IN VIVO

Discovery of DDO-4279 as a PP5 degrader for the treatment of obesity

Gu M, Yang H, Tang M, et al.

RSC medicinal chemistry, 2026

Semaglutide
PRECLINICAL / IN VIVO

Differential Anti-Inflammatory Effects of Semaglutide and Tirzepatide in Experimental Diabetes Mellitus

Dobriceanu RC, Boboc IKS, Tartau LM, et al.

Current issues in molecular biology, 2026;48(7)

Semaglutide tirzepatide
PRECLINICAL / IN VIVO

A trispecific GLP-1/anti-GIPR/FGF21 peptibody exhibits favorable metabolic effects in a diet-induced obesity model

Liu Y, Liu X

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2026;201:119717

GLP-1 tirzepatide
PRECLINICAL / IN VIVO

GLP-1 Receptor Agonists and the Ocular Surface: A Narrative Review of Restoration, Remodeling, and Clinical Implications

Bair H, Orlick M, Syed ZA

Ophthalmology and therapy, 2026

GLP-1 Semaglutide
PRECLINICAL / IN VIVO

Chronic semaglutide alters ingestive behavior without impairing taste function in mice

Acosta AA, Ellis H, Hsu FY, et al.

Molecular metabolism, 2026;:102410

Semaglutide
PRECLINICAL / IN VIVO

From dual to quintuple agonism for next-generation pharmacology to treat obesity and type 2 diabetes: synergistic incretin and nuclear receptor signaling

Santulli G

Cardiovascular diabetology. Endocrinology reports, 2026;12(1)

GLP-1 Semaglutide
PRECLINICAL / IN VIVO

Hydrophobic ion pairing formed semaglutide designed for oral self-microemulsifying delivery in diabetes treatment

Zhang Y, Cheng J, Wang H, et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2026;:115167

GLP-1 Semaglutide
PRECLINICAL / IN VIVO

Tirzepatide, a dual GIP/GLP-1 receptor agonist, attenuates endothelial dysfunction and angiotensin II-induced abdominal aortic aneurysm in ApoE-/- mice

Gómez-Martín Á, Marques P, Arce-Recatalá C, et al.

Pharmacological research, 2026;:108321

GLP-1 tirzepatide
PRECLINICAL / IN VIVO

Development and Validation of a Liquid Chromatography/Tandem Mass Spectrometry Method for the Quantification of the GLP-1 Analog Semaglutide in Rat Plasma, and Its Application in a Pharmacokinetic Study

Kim JM, Kim KA, Yu NY, et al.

Pharmaceutics, 2026;18(7)

GLP-1 Semaglutide
PRECLINICAL / IN VIVO

Semaglutide alleviates osteoarthritis independent of weight loss via GLP-1R-mediated activation of autophagy through AKT/mTOR inhibition

Lin J, Luo M, Tang H, et al.

Journal of orthopaedic translation, 2026;59:101166

Semaglutide

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