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RESEARCH STUDY
[Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging]
Abstract
The decrease of lymphocyte interferon gamma expression during aging is one of the main mechanisms leading to the immunodeficiency state in the elderly. Cell penetrating geroprotective peptide Ala-Glu-Asp-Gly has the capability to activate the proliferation of lymphocytes in thymus during its aging. The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene. Thus, the immune protection of this peptide can be explained by its activation of the interferon gamma production in T-cells.
Authors: N S Lin'kova, B I Kuznik, V Kh Khavinson
Journal: Advances in gerontology = Uspekhi gerontologii