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RESEARCH STUDY
Short cell-penetrating peptides: a model of interactions with gene promoter sites
Abstract
Analysis of the main parameters of molecular mechanics (number of hydrogen bonds, hydrophobic and electrostatic interactions, DNA-peptide complex minimization energy) provided the data to validate the previously proposed qualitative models of peptide-DNA interactions and to evaluate their quantitative characteristics. Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.
Authors: V Kh Khavinson, S I Tarnovskaya, N S Linkova, V E Pronyaeva, L K Shataeva, P P Yakutseni
Journal: Bulletin of experimental biology and medicine